Pagoclone Pellets 10mg, a potent cyclopyrrolone derivative, serve as an essential tool in neuropharmacological research, particularly for exploring GABAA receptor modulation and anxiolytic mechanisms. As a partial agonist, Pagoclone Pellets 10mg for research offer precise 10mg dosing per pellet, enabling consistent studies on chloride channel conductance and synaptic inhibition without the inconsistencies of bulk powders. Our 99% pure Pagoclone Pellets 10mg are synthesized under strict controls to ensure impurity-free performance, making them ideal for in vitro receptor binding assays or electrophysiological investigations.
Laboratories worldwide rely on buy Pagoclone Pellets 10mg for research to probe partial agonism profiles, fostering insights into benzodiazepine alternatives. With optimized pellet formulation for easy handling, order Pagoclone Pellets 10mg online to streamline your protocols in GABAergic signaling research. Committed to scientific integrity, we provide this exclusively for legitimate lab use, supporting ethical advancements in neuroscience.
Physical and Chemical Properties:
- Appearance: White to off-white cylindrical pellets, facilitating precise laboratory manipulation.
- Molecular Formula: C₁₇H₁₄Cl₂N₂O, structured for targeted GABAA receptor interactions.
- Molecular Weight: 349.22 g/mol, supporting accurate quantitative dosing.
- CAS Number: 133737-32-3, a standardized reference for global research documentation.
- Solubility: Soluble in DMSO and ethanol; moderately soluble in water, suitable for diverse assay buffers.
- Dose per Pellet: 10mg of active Pagoclone, with inert excipients for stability and uniformity.
(148 words)
Introduction
In the sophisticated arena of GABAA receptor pharmacology, Pagoclone Pellets 10mg emerge as a refined instrument for scientists investigating partial agonism and its implications for synaptic modulation. As a cyclopyrrolone-class compound, Pagoclone provides a nuanced profile distinct from full agonists like benzodiazepines, allowing researchers to dissect selective chloride influx and anxiolytic-like effects in controlled models. With 99% pure Pagoclone Pellets 10mg, laboratories achieve the precision necessary for reproducible outcomes in binding affinity studies or patch-clamp electrophysiology.
The appeal of purchase Pagoclone 10mg research pellets extends to its therapeutic index advantages, as evidenced in preclinical paradigms, making it a staple for exploring novel anxiolytics. For European and international researchers seeking the best price Pagoclone Pellets 10mg, our offerings blend superior synthesis with accessible economics, ensuring your focus stays on hypothesis-driven discovery. Get Pagoclone 10mg pellets for lab use today to illuminate the subtleties of GABAergic signaling, transforming experimental data into foundational knowledge for future innovations.
Key Features & Benefits
Empower your neuropharmacology endeavors with Pagoclone Pellets 10mg for research, crafted for optimal performance and ease. Discover why experts order Pagoclone Pellets 10mg online:
- Elite 99%+ Purity: 99% pure Pagoclone Pellets 10mg are refined to surpass analytical thresholds, eliminating contaminants that could confound receptor selectivity data in GABAA assays.
- Precision Pellet Dosing: Each 10mg pellet ensures uniform delivery, minimizing variability in dose-response curves and enhancing throughput in high-precision experiments.
- Unparalleled Discretion: Vacuum-sealed, plain packaging with no identifiers protects your research confidentiality, allowing seamless integration into sensitive protocols.
- Expedited Global Reach: Swift shipping delivers to Europe in mere days and worldwide within a week, accelerating your timelines without compromise.
These hallmarks position buy Pagoclone Pellets 10mg for research as more than a reagent—it’s a catalyst for breakthrough insights, persuasively bridging quality and convenience.
Product Specifications
Engineered for exacting standards, our Pagoclone 10mg research pellets feature comprehensive specifications to underpin rigorous applications:
| Property | Specification |
|---|---|
| IUPAC Name | 2-(3-Chlorophenyl)-5-(2-chlorophenyl)-1,3-diazaspiro[4.4]non-1-ene-4-one |
| Synonyms | Pagoclone, Cyclopyrrolone derivative |
| Molecular Formula | C₁₇H₁₄Cl₂N₂O |
| Molecular Weight | 349.22 g/mol |
| CAS Number | 133737-32-3 |
| Appearance | White to off-white pellets |
| Solubility | Soluble in DMSO (>10 mg/mL), ethanol; moderate in water |
| Melting Point | Approximately 180-185°C (estimated for base) |
| Dose Strength | 10mg per pellet, uniform excipients |
| Storage Conditions | Cool, dry, dark; -20°C for longevity |
These properties optimize best price Pagoclone Pellets 10mg for solubility in electrophysiological buffers or radioligand preparations, guaranteeing consistent experimental fidelity.
Applications & Usage
Pagoclone Pellets 10mg for research shine in neuroscientific explorations, particularly GABAA receptor subtype selectivity and partial agonism dynamics, as referenced in protocols from British Journal of Pharmacology. Researchers deploy them in radioligand binding assays to quantify affinities at α2/α3 subunits, contrasting with diazepam benchmarks to map anxiolytic potential sans sedation.
Toxicological evaluations benefit from purchase Pagoclone 10mg research pellets, modeling metabolic clearance via hepatocyte incubations per OECD guidelines, assessing CYP450 interactions. In analytical chemistry, they validate HPLC-MS methods for cyclopyrrolone detection in biofluid simulations. The 10mg format suits microdosing for neuronal culture studies or voltage-clamp recordings, probing chloride currents with precision. Strictly lab-oriented, 99% pure Pagoclone Pellets 10mg propel ethical progress in receptor pharmacology, informing safer therapeutic scaffolds.
Purity & Testing
Reliability in Pagoclone Pellets 10mg for research stems from >99% purity, fortified by multifaceted validation to avert experimental artifacts:
High-Performance Liquid Chromatography (HPLC) delineates the active at >99.5%, detecting impurities below 0.05%. Nuclear Magnetic Resonance (NMR) authenticates the spiro structure via diagnostic peaks for chlorophenyl moieties. Mass Spectrometry (MS) affirms [M+H]+ at m/z 350, aligned with spectral libraries for stereochemical integrity.
CoAs encapsulate these assays, including residual solvents (<0.1%), ensuring get Pagoclone 10mg pellets for lab use yields data mirroring literature standards—crucial for GABAA Ki determinations and grant validations.
Safety & Handling Guidelines
Pagoclone Pellets 10mg for research necessitate meticulous protocols given their GABAA affinity, confined to laboratory contexts only:
Core Protocols:
- PPE: Employ nitrile gloves, safety eyewear, and fume extraction to preclude exposure.
- Storage: Maintain in desiccated, amber vials at -20°C, shielded from humidity and light.
- Spill Mitigation: Absorb with inert material, ventilate, and dispose via hazardous protocols.
- Hazard Notes: Irritant potential; SDS details LD50 metrics for non-ingestive reference.
Upholding these safeguards ensures order Pagoclone Pellets 10mg online bolsters safe, productive inquiry.
Global Shipping & Discreet Delivery
Pagoclone Pellets 10mg transit worldwide via stealth-optimized channels: unmarked, vacuum-sealed parcels devoid of chemical cues, masquerading as routine lab goods. Premium couriers assure European arrival in 3-5 days, global in 7-10, with encrypted oversight. Buy Pagoclone Pellets 10mg for research arrives incognito, fortifying your operational discretion.
Why Choose Us?
Partner with us for purchase Pagoclone 10mg research pellets and reap:
- Swift Fulfillment: 24-hour processing for urgent lab demands.
- Stealth Supremacy: Layered, odor-proof sealing for total anonymity.
- Advisory Excellence: PhD-backed support for assay optimization.
- Enduring Credibility: Decade-long service to 4,000+ labs, 100% delivery fidelity.
At the best price Pagoclone Pellets 10mg, we deliver partnership, not mere product.
Legal & Safety Disclaimer
Pagoclone Pellets 10mg are designated solely for research in controlled settings, prohibiting human or animal consumption, diagnostics, or therapeutics. Acquirers must be 18+, credentialed, and law-abiding; we disclaim misuse liability. Affirm local compliance before get Pagoclone 10mg pellets for lab use.
FAQ
What is Pagoclone Pellets 10mg used for in research?
Pagoclone Pellets 10mg for research facilitate GABAA partial agonism studies, binding assays, and chloride channel modulation, aiding anxiolytic mechanism explorations.
Is Pagoclone Pellets 10mg legal?
Status varies jurisdictionally; research-grade in select areas, potentially analog-restricted elsewhere. Validate laws prior to buy Pagoclone Pellets 10mg for research.
How discreet is the shipping?
Utterly confidential: plain, vacuum-sealed, label-free parcels for 99% pure Pagoclone Pellets 10mg, with secure global conveyance.
What is the purity level?
Batches exceed 99%, certified for unadulterated GABAA research utility.
How is purity tested?
HPLC quantifies actives, NMR verifies structure, MS confirms mass—CoAs attest >99% for purchase Pagoclone 10mg research pellets.
